Reactions of acyl phosphonates with organoaluminum reagents: a new method for the synthesis of secondary and tertiary α-hydroxy phosphonates
نویسندگان
چکیده
منابع مشابه
The asymmetric synthesis of chiral cyclic α-hydroxy phosphonates and quaternary cyclic α-hydroxy phosphonates.
A highly practical, catalytic enantioselective cyclic phosphite addition to aldehydes and ketones was developed. The reaction rate of the asymmetric hydrophosphonylation was significantly enhanced by the addition of silver carbonate. Particularly, significant improvement has been achieved on the asymmetric hydrophosphonylation of unactivated ketones, giving quaternary α-hydroxy phosphonates wit...
متن کاملnano-rods zno as an efficient catalyst for the synthesis of chromene phosphonates, direct amidation and formylation of amines
چکیده ندارد.
New synthesis and reactions of phosphonates
The importance of phosphorus can be highlighted not only through its biological significance, but also in its many varied industrial, medicinal, and synthetic applications. Phosphonate moieties in particular have broad applications including their use as reagents in the Horner-Wadsworth-Emmons olefination reaction, a widely used synthetic strategy. As an alternative to the often harsh condition...
متن کاملApplication of H2O as the Green Solvent for the Synthesis of Phosphonates via Multicomponent Reactions
Phosphonate derivatives were prepared using multicomponent reactions of dialkyl acetylenedicarboxylate with 4-hydroxycumarine in the presence of trimethyl or triphenyl phosphite in good yields.
متن کاملAsymmetric organocatalytic synthesis of quaternary α-hydroxy phosphonates: en route to α-aryl phosphaisoserines.
The dual activation of acyl phosphonates and formaldehyde tert-butyl hydrazone by a BINAM-derived bis-urea catalyst is the key to achieve high reactivities and enantioselectivities in the synthesis of densely functionalized quaternary α-hydroxy phosphonates. Subsequent high-yielding transformations in a 'one-pot' fashion provide direct access to valuable azoxy compounds and quaternary α-aryl-ph...
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2011
ISSN: 0040-4020
DOI: 10.1016/j.tet.2011.03.036